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SHR2415
$362 – $4,478
Products Details
Product Description
– SHR2415 is a highly potent, selective and orally active ERK1/2 inhibitor. SHR2415 has inhibition activity for ERK1 and ERK2 with IC50 values of 2.8 nM and 5.9 nM, respectively. SHR2415 exhibits high potency with an IC50 value of 44.6 nM in Colo205 cells. SHR2415 can be used for the research of cancer[1].
Web ID
– HY-151367
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H22ClN7O2
References
– [1]Xin Li, et al. Discovery of SHR2415, a Novel Pyrrole-Fused Urea Scaffold ERK1/2 Inhibitor. ACS Med Chem Lett. 2022 Apr 1;13(4):701-706.
CAS Number
– 2494010-42-1
Molecular Weight
– 463.92
Compound Purity
– 98.63
SMILES
– CC1=CN=C(N=C1C2=CN3C(N(CC3=C2)[C@@H](C4=CC(Cl)=CC=C4)CO)=O)NC5=CC=NN5C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– ERK
Isoform
– ERK1;ERK2
Pathway
– MAPK/ERK Pathway;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
