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SAG

SKU T1779-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 72 CAD through 1,274 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1779

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H28ClN3OS

Citations

– 1. Schenke M, Schjeide B M, Püschel G P, et al. Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays. Toxins. 2020, 12(5): 276 2. Yang Y, Suo N, Cui S, et al.Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2024: 1-13.

References

– Xu H, et al. Directed Differentiation of V3 Interneurons from Mouse Embryonic Stem Cells. Stem Cells Dev. 2015 Nov 15;24(22):2723-32.

CAS Number

– 912545-86-9

Molecular Weight

– C28H28ClN3OS

Compound Purity

– 0.9888

SMILES

– CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2ccccc2c1Cl

Target

– Others

Pathway

– Stem Cells|||GPCR/G Protein

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.