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RU.521

SKU T5486-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 66 CAD through 1,342 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– RU.521 (RU3205217) is a potent dsDNA inhibitor (IC50: 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T5486

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H12Cl2N4O3

Citations

– 1. Li B, Xu L, Wang Z, et al.Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway.Cellular and Molecular Neurobiology.2024, 44(1): 36. 2. Wang Z, Zhang X, Luo Y, et al.Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis).Cell Death & Disease.2024, 15(5): 375.

References

– Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.

CAS Number

– 2262452-06-0

Molecular Weight

– C19H12Cl2N4O3

Compound Purity

– 0.9982

SMILES

– Cc1nn(c(O)c1C1OC(=O)c2ccccc12)-c1nc2ccc(Cl)c(Cl)c2[nH]1

Pathway

– Immunology/Inflammation|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.