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Products Details
Product Description
– (R)-HH2853 is a mutant EZH2 inhibitor with an IC50 of <100 nM for EZH2-Y641F. (R)-HH2853 can be used for cancer and autoimmune diseases (WO2018045971A1; compound 201)[1].
Web ID
– HY-144882
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H36F3N7O3
References
– [1]Xuxing Chen, et al. Pyrido five-element aromatic ring compound, preparation method therefor and use thereof. WO2018045971A1.
CAS Number
– 2202678-06-4
Molecular Weight
– 611.66
SMILES
– C[C@@H](N1CCN(CC1)CC(F)(F)F)C2=C(C)C(C(NCC3=C(C=C(NC3=O)C)OC)=O)=CC4=C(C5=CC=C(N=N5)C)C=CN24
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Isoform
– EZH2
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
