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(R)-ADX-47273
$140 – $720
Products Details
Product Description
– (R)-ADX-47273 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .
Web ID
– HY-13058B
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H17F2N3O2
References
– [1]Engers DW, et al. Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr;4(4):505-11.
CAS Number
– 851881-59-9
Molecular Weight
– 369.36
Compound Purity
– 99.00
SMILES
– O=C(N1C[C@H](C2=NC(C3=CC=C(C=C3)F)=NO2)CCC1)C4=CC=C(C=C4)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– mGluR
Isoform
– mGluR5
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
