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Products Details
Product Description
– PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI=2.71 and 4.27, respectively). PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs)[1].
Web ID
– HY-151174
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C34H35NO6
References
– [1]Liu H, et al. Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur J Med Chem. 2022 Aug 9;242:114631.
CAS Number
– 2901084-32-8
Molecular Weight
– 553.64
SMILES
– COC1=C(C=C2OC3=C(C(OCC4=CC=NC=C4)=C5C=CC(C)(OC5=C3)C)C(C2=C1C/C=C(C)C)=O)OCC6CC6
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– PDE10;PDE4;PDE5;PDE7;PDE8
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
