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Products Details
Product Description
– LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL)[1].
Web ID
– HY-151194
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H8BrF2N
References
– [1]Hideaki Niwa, et al. Structure−Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.2c00294
CAS Number
– 2821068-09-9
Molecular Weight
– 248.07
SMILES
– N[C@@H]1C[C@H]1C2=CC(F)=C(Br)C(F)=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Demethylase
Isoform
– KDM1/LSD1
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
