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Products Details
Product Description
– Lp-PLA2-IN-10 is a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2). Lp-PLA2 previously known as platelet- activating factor acetylhydrolase (PAF-AH), is a phospholipase A2 enzyme involved in hydrolysis of lipoprotein lipids or phospholipids. Lp-PLA2-IN-10 has the potential for the research of neurodegenerative-related diseases such as Alzheimer’s disease (AD), glaucoma, age-related macular degeneration (AMD), or cardiovascular diseases including atherosclerosis (extracted from patent WO2022001881A1, compound 4)[1].
Web ID
– HY-142778
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C21H15F5N4O4
References
– [1]Zhenhua Gu, et al. Bridging cyclic pyrimidinones, methods of preparation thereof, compositions thereof and uses. Patent WO2022001881A1.
CAS Number
– 2756855-45-3
Molecular Weight
– 482.36
SMILES
– O=C1N=C(C2=C3N(CCN13)CCO2)OCC4=CC(F)=C(C(F)=C4)OC5=CC(C(F)(F)F)=NC=C5
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Phospholipase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
