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Products Details
Product Description
– IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease[1].
Web ID
– HY-150732
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C24H25FN6O3
References
– [1]Chen Y, et al. Bicyclic pyrimidine compounds as potent IRAK4 inhibitors. Bioorg Med Chem Lett. 2022 Jul 18:128900.
Molecular Weight
– 464.49
SMILES
– O=C(N)[C@@H]1C([C@@H]2C[C@H]1C=C2)NC3=NC(NC4=CC(N5CCOCC5)=CC(F)=C4)=NC6=C3OC=C6
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– IRAK
Isoform
– IRAK4
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
