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Products Details
Product Description
– Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM[1].
Web ID
– HY-149034
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C104H142N28O24S
References
– [1]Pascha MN, et al. Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region. ACS Chem Biol. 2022 Aug 4.
Molecular Weight
– 2200.48
SMILES
– O=C(NCC(N)=O)[C@H](CSCC1=O)NC([C@H](C(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC4=CN=CN4)NC([C@@]([C@@H](C)O)([H])NC([C@H](C)NC([C@H](CC(C)C)NC([C@@]([C@H](O)C)([H])NC(CNC([C@H](CC5=CN=CN5)NC([C@H](CC(O)=O)NC([C@H](CC6=CNC7=C6C=CC=C7)NC([C@H](CCCNC(N)=N)NC([C@H](CC8=CC=CC=C8)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H](N1[H])CC9=CC=C(O)C=C9)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Influenza Virus
Pathway
– Anti-infection
Product type
– Peptides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
