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Hymeglusin
$720 – $1,150
Products Details
Product Description
– Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].
Web ID
– HY-117430
Storage Temperature
– -20°C (Powder, stored under nitrogen, away from moisture)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C18H28O5
References
– [1]Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389(1-2):18-19.|[2] Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92.|[3] Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.
CAS Number
– 29066-42-0
Molecular Weight
– 324.41
Compound Purity
– 98.0
SMILES
– O=C(O)/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@H]([C@H]1CO)OC1=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Flavivirus
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
