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Products Details
Product Description
– HSP90-IN-10 (Compound 16s) is a potent inhibitor of HSP90. HSP90-IN-10 exhibits high antiproliferative potency against HCC1954 breast cancer cells with the IC50 value of 6 µM. HSP90-IN-10 does not inhibit the growth of normal epithelial cells. HSP90-IN-10 also induces apoptosis[1].
Web ID
– HY-144724
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H26FN3O6
References
– [1]Piven YA, et al. Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes targeting HSP90-HER2 axis in breast cancer cells. Bioorg Med Chem. 2022 Jan 1;53:116521.
CAS Number
– 2881071-86-7
Molecular Weight
– 543.54
SMILES
– COC1=CC(C2=C3C(CC(C)(C/C3=NOC(C4=CC(NC(C5=CC(F)=CC=C5)=O)=CC=C4)=O)C)=NO2)=CC=C1O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;HSP
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
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