Gambogic Acid

SKU T6185-1 mL * 10 mM (in DMSO) Category Natural Product Brand: TargetMol

Price range: 53 CAD through 942 CAD

Size

2 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg 500 mg

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Product Description

– Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.

Web ID

– T6185

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C38H44O8

Citations

– 1. Liu X, Hu Q, Wang W, et al. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer. Biochemical Pharmacology. 2021, 188: 114583.

References

– Zhai D, et al. Mol Cancer Ther, 2008, 7(6), 1639-1646.

CAS Number

– 2752-65-0

Molecular Weight

– C38H44O8

Compound Purity

– 0.9867

SMILES

– CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(O)=C2C=C1)C(=O)C1=CC2CC4C(C)(C)OC(CC=C(/C)C(O)=O)(C2=O)C14O3

Pathway

– Autophagy|||Apoptosis

Product type

– Natural Product

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Gambogic Acid

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