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Fludarabine triphosphate (trisodium)
$105 – $3,000
Products Details
Product Description
– Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1][2].
Web ID
– HY-136650A
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C10H12FN5Na3O13P3
References
– [1]Catapano CV, et al. Inhibition of primer RNA formation in CCRF-CEM leukemia cells by fludarabine triphosphate. Cancer Res. 1991 Apr 1;51(7):1829-35. |[2]Woodahl EL, et al. A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patients. Cancer Chemother Pharmacol. 2009 Feb;63(3):391-401.
Molecular Weight
– 591.12
Compound Purity
– 95.0
SMILES
– O[C@@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])N2C3=NC(F)=NC(N)=C3N=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– H2O : 125 mg/mL (ultrasonic)
Target
– Apoptosis;DNA/RNA Synthesis;Drug Metabolite;Nucleoside Antimetabolite/Analog
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
