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Products Details
Product Description
– FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK). FAK-IN-3 not only decreases migration and invasion of PA-1 cells, but also reduces expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis, and no obvious adverse effects. FAK-IN-3 has the potential for the research of ovarian cancer[1].
Web ID
– HY-143407
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H28N6O4
References
– [1]Wei W, et al. Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer. Eur J Med Chem. 2022;228:113978.
CAS Number
– 2882094-29-1
Molecular Weight
– 512.56
SMILES
– COC1=CC(C(NC2CCNCC2)=O)=CC=C1NC3=NC4=C(C(OC5=CC=CC6=C5C(CC6)=O)=N3)C=CN4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FAK
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
