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Dacomitinib
Price range: 51 CAD through 1,230 CAD
Products Details
Product Description
– Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
Web ID
– T2483
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C24H25ClFN5O2
Citations
– 1. Fujimura T, Furugaki K, Mizuta H, et al.Targeting ErbB and tankyrase1/2 prevent the emergence of drug-tolerant persister cells in ALK-positive lung cancer.npj Precision Oncology.2024, 8(1): 1-16.
References
– Engelman JA, et al, Cancer Res, 2007, 67(24), 11924-11932.
CAS Number
– 1110813-31-4
Molecular Weight
– C24H25ClFN5O2
Compound Purity
– 0.9972
SMILES
– COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN1CCCCC1
Pathway
– Apoptosis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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