Download Files:
Benpyrine
$400 – $3,400
Products Details
Product Description
– Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 µM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].
Web ID
– HY-133807
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16H16N6O
References
– [1]Weiguang Sun, et al. Discovery of an Orally Active Small Molecule TNF-α Inhibitor. J Med Chem. 2020 Jul 15.
CAS Number
– 2550398-89-3
Molecular Weight
– 308.34
Compound Purity
– 99.74
SMILES
– O=C(N(CC1=CC=CC=C1)C2)C[C@@H]2NC3=C4C(NC=N4)=NC=N3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 12.5 mg/mL (ultrasonic)
Target
– TNF Receptor
Isoform
– CD40
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
