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Anisomycin
Price range: 74 CAD through 360 CAD
Products Details
Product Description
– Anisomycin is an antibiotic and protein synthesis inhibitor produced by Streptomyces griseolus. It is also a classic activator of p38 MAPK and JNK. By inhibiting protein synthesis, anisomycin induces cellular stress, which activates upstream kinases and subsequently leads to the phosphorylation and activation of p38 MAPK and JNK.
Web ID
– T6758
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C14H19NO4
Citations
– 1. Chen L, Zhou X, Kong X, et al. The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time. Frontiers in Cell and Developmental Biology. 2021 Mar 9;9:656693. doi: 10.3389/fcell.2021.656693. eCollection 2021.
2. Liu Y J, Chang Y J, Kuo Y T, et al. Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma. Carcinogenesis. 2020, 41(5): 699-710
3. Zhang L, Liu W, Wu N, et al.Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect.PLoS pathogens.2023, 19(1): e1011134.
References
– Slipicevic A, et al. Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis. Cancer Biol Ther. 2013 Feb;14(2):146-54.
CAS Number
– 22862-76-6
Molecular Weight
– C14H19NO4
Compound Purity
– 0.9966
SMILES
– COc1ccc(CC2NCC(O)C2OC(C)=O)cc1
Pathway
– Apoptosis|||DNA Damage/DNA Repair|||MAPK|||Cell Cycle/Checkpoint|||Microbiology/Virology
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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