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Aficamten
$230 – $1,840
Products Details
Product Description
– Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM)[1].
Web ID
– HY-139465
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H19N5O2
References
– [1]Chihyuan Chuang, et al. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. J Med Chem. 2021 Oct 14;64(19):14142-14152.
CAS Number
– 2364554-48-1
Molecular Weight
– 337.38
Compound Purity
– 99.86
SMILES
– O=C(C1=CN(C)N=C1)N[C@H]2C3=CC=C(C4=NOC(CC)=N4)C=C3CC2
Clinical Information
– Phase 3
Research Area
– Cardiovascular Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Myosin
Pathway
– Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
