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Products Details
Product Description
– AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC50 values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer’s disease[1].
Web ID
– HY-150728
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C21H20N4O5S
References
– [1]Chuang Han, et al. Design, synthesis and evaluation of 2-(2-oxoethyl)pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett. 2022 Sep 15;72:128873.
Molecular Weight
– 440.47
SMILES
– O=C(C1=CC=CS1)CC2=NC=C(C=N2)C(N(CCCOC3=CC=C(C=C3)[N+]([O-])=O)C)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
