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Products Details
Product Description
– AChE-IN-10 (Compound 24r) is a potent inhibitor of AChE (IC50 = 2.4 nM). AChE-IN-10 potently inhibits AChE, reduces tau phosphorylation at S396 residue, provides neuroprotection by rescuing neuronal morphology and increasing cell viability. AChE-IN-10 is also found to reduce amyloid aggregation in the presence of AChE[1].
Web ID
– HY-144775
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C23H27F2NO4S
References
– [1] Liu Y, et al. Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer’s disease. Eur J Med Chem. 2022 May 5;235:114305.
CAS Number
– 2770832-90-9
Molecular Weight
– 451.53
SMILES
– COC1=C(C=C2C(CC(CC3CCN(CC3)CC4=CC=CC(F)=C4)(S2(=O)=O)F)=C1)OC
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
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