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Abaloparatide
$170 – $520
Products Details
Product Description
– Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis[1][2].
Web ID
– HY-108742
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C174H300N56O49
References
– [1]Sahbani K, et al. Abaloparatide exhibits greater osteoanabolic response and higher cAMP stimulation and β-arrestin recruitment than teriparatide. Physiol Rep. 2019 Oct;7(19):e14225.|[2]Varela A, et al. One Year of Abaloparatide, a Selective Activator of the PTH1 Receptor, Increased Bone Formation and Bone Mass in Osteopenic Ovariectomized Rats Without Increasing Bone Resorption. J Bone Miner Res. 2017 Jan;32(1):24-33.
CAS Number
– 247062-33-5
Molecular Weight
– 3960.59
Compound Purity
– 99.94
SMILES
– [AVSEHQLLHDKGKSIQDLRRRELLEKLL-{Aib}-KLHTA-NH2]
Clinical Information
– Launched
Research Area
– Metabolic Disease
Solubility
– DMSO : 25 mg/mL (ultrasonic)
Target
– Arrestin;Thyroid Hormone Receptor
Pathway
– GPCR/G Protein;Vitamin D Related/Nuclear Receptor
Product type
– Peptides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
