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(1R,2R)-ML-SI3
$350 – $2,800
Products Details
Product Description
– (1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3[1].
Web ID
– HY-134819A
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H31N3O3S
References
– [1]Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966.
CAS Number
– 2418594-00-8
Molecular Weight
– 429.58
Compound Purity
– 99.45
SMILES
– COC1=CC=CC=C1N2CCN([C@@H]3CCCC[C@H]3NS(C4=CC=CC=C4)(=O)=O)CC2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– TRP Channel
Isoform
– TRPML
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
