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Products Details
Product Description
– (±)-threo-3-Methylglutamic acid is a potent EAAT2/4 inhibitor. (±)-threo-3-Methylglutamic acid also is an ionotropic glutamate receptor agonist. (±)-threo-3-Methylglutamic acid inhibits glutamate uptake by rod outer segments[1][2].
Web ID
– HY-101227
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C6H11NO4
References
– [1]Eliasof S, et al. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7.|[2]Pignataro L, et al. Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors. Mol Cell Neurosci. 2005 Mar;28(3):440-51.
CAS Number
– 63088-04-0
Molecular Weight
– 161.16
SMILES
– OC([C@@H](N)[C@H](C)CC(O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– EAAT
Isoform
– EAAT2;EAAT4
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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