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Avasopasem manganese
$800 – $6,800
Products Details
Product Description
– Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].
Web ID
– HY-109110
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H35Cl2MnN5
References
– [1]Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38(3):288]. J Clin Oncol. 2019;37(34):3256-3265.
CAS Number
– 435327-40-5
Molecular Weight
– 483.38
Compound Purity
– 96.02
SMILES
– [Cl-][Mn+2]1234([N]5=C6C[NH]1[C@](CCCC7)([H])[C@@]7([H])[NH]2CC[NH]3[C@]8([H])[C@@](CCCC8)([H])[NH]4CC5=CC=C6)[Cl-]
Clinical Information
– Phase 3
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : ≥ 230 mg/mL
Target
– Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
