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MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1)(2F6), CF568 conjugate, 0.1mg/mL

SKU BT-A-BNC680316 Category Biotium Antibodies Brand: Biotium

Price range: 318 CAD through 882 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.Intended for use by research organizations and laboratories only; not for patients or for personal use.

Size

100 μL 500 μL

Clear

Products Details

Product Description

–

Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli, including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (MEK kinase- 5). MEK kinase-1 activates the ERK and c-Jun NH2-terminal kinase (JNK) pathways by phosphorylation of MAP2K1 and MAP2K4, and also activates the central protein kinases of the NFB pathway, CHUK and IKBKB. Additionally, MEK kinase-1 uses an E3 ligase through its PHD domain, a RING-finger-like structure, to target proteins for degradation through ubiquitination.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, [cosmetic chemistry research literature], or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Storage Temperature

– 2-8 °C (Refrigerator)

Shipping

– Room temperature

Applications

– IHC, FFPE (verified)

Antibody Type

– Primary

Antibody Host

– Mouse

Antibody Isotype

– IgG2a, kappa

Molecular Weight

Clinical Information

– A431, HeLa or HL-60 cells. Liver tissue.

Target

– MAP3K1

Product type

– Primary Antibody

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.