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LY450108
$220 – $1,570
Products Details
Product Description
– LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson’s disease research[1][2][3][4].
Web ID
– HY-10935
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H22F2N2O3S
References
– [1]Simon E Ward1, Benjamin D Bax, Mark Harries. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology. 2010,160(2):181-190.|[2]O’Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson’s disease. Curr Drug Targets. 2007 May;8(5):603-20.|[3]Jhee SS, Chappell AS, Zarotsky V, et al. Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. J Clin Pharmacol. 2006 Apr;46(4):424-32.|[4]Douglas A. Schober, Martin B. Gill, Hong Yu, et al. Transmembrane AMPA Receptor Regulatory Proteins and Cornichon-2 Allosterically Regulate AMPA Receptor Antagonists and Potentiators. The Journal of Biological Chemistry, 286, 13134-13142.
CAS Number
– 376594-67-1
Molecular Weight
– 396.45
Compound Purity
– 99.51
SMILES
– FC1=CC(F)=CC(C(NC2=CC=C([C@@H](C)CNS(C(C)C)(=O)=O)C=C2)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 50 mg/mL|H2O : 1 mg/mL (ultrasonic;warming)
Target
– iGluR
Isoform
– AMPA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
