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Products Details
Product Description
– L-803087 TFA is a potent and selective somatostatin sst4 receptor agonist with a Ki of 0.7 nM. L-803087 TFA is >280-fold more selective for sst4 receptor than other somatostatin receptors. L-803087 TFA facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice[1][2].
Web ID
– HY-108497A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H30F5N5O5
References
– [1]Rohrer SP, et al. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40.|[2]Moneta D, et al. Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur J Neurosci. 2002 Sep;16(5):843-9.
CAS Number
– 1786412-46-1
Molecular Weight
– 599.55
SMILES
– FC(F)(C(O)=O)F.N=C(N)NCCC[C@@H](C(OC)=O)NC(CCCC1=C(C2=CC=CC=C2)NC3=C1C=C(F)C=C3F)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Somatostatin Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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