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MPP (dihydrochloride)
$420
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Products Details
Product Description
– MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3].
Web ID
– HY-103454
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H33Cl2N3O3
Citations
– Biomolecules. 2023 Jul 10, 13(7), 1097.|Drug Resist Updat. 2023 Oct 26:71:101014.|Ecotoxicol Environ Saf. 2023 May 23;259:115060.|Eur J Inflamm. October 11, 2021.|Mol Nutr Food Res. 2021 Jul 5;e2100070.|Phytomedicine. 2023 Nov 14:123:155218.|Phytomedicine. 27 February 2022, 154022.|Food Chem Toxicol. 2023 Apr 18;113792.|Metab Brain Dis. 2022 Jul 2.
References
– [1]KaraboÄŸa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672.|[2]Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94.|[3]Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73(8):1034-44.
CAS Number
– 911295-24-4
Molecular Weight
– 542.50
Compound Purity
– 99.06
SMILES
– OC1=CC=C(C2=NN(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)=C2C)C=C1.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Endocrinology
Solubility
– DMSO : 30 mg/mL (ultrasonic;warming)
Target
– Apoptosis;Estrogen Receptor/ERR
Isoform
– ERα;ERβ
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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