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GITR / Tnfrsf18 (Mouse)(DTA-1), CF740 conjugate, 0.1mg/mL

SKU BT-A-BNC740976 Categories Biotium Antibodies, Immunology, Inflammation Brand: Biotium

Price range: 328 CAD through 896 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.Intended for use by research organizations and laboratories only; not for patients or for personal use.

Size

100 μL 500 μL

Clear

Products Details

Product Description

–

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, [cosmetic chemistry research literature], or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Storage Temperature

– 2-8 °C (Refrigerator)

Shipping

– Room temperature

Applications

– Flow, surface (published), Functional studies (published)

Antibody Type

– Primary

Antibody Host

– Rat

Antibody Isotype

– IgG2b, kappa

Molecular Weight

Clinical Information

– CD25 CD4 Tregs.

Research Area

– Immunology, Inflammation

Target

– GITR, Tnfrsf18

Product type

– Primary Antibody

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.