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AM-6538
$450 – $3,500
Products Details
Product Description
– AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may be useful in future studies that require temporary reductions in cannabinoid receptor availability[1]. AM-6538 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-120423
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H25Cl2N5O4
References
– [1]Paronis CA, et al. Long-Lasting In Vivo Effects of the Cannabinoid CB1 Antagonist AM6538. J Pharmacol Exp Ther. 2018;364(3):485-493.
CAS Number
– 1245626-00-9
Molecular Weight
– 542.41
Compound Purity
– 99.73
SMILES
– O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CCCO[N+]([O-])=O)C=C3)=C1C)NN4CCCCC4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 180 mg/mL (ultrasonic)
Target
– Cannabinoid Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
