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Meclofenamic acid
$100
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Products Details
Product Description
– Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4].
Web ID
– HY-117275
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C14H11Cl2NO2
Citations
– Biomed Opt Express. 2021 Mar 9.|Biomater Adv. 2023 Sep 22, 213634.|Sensor Actuat B-Chem. 2021, 129983.|Theranostics. 2021 Jul 25;11(17):8464-8479.
References
– [1]Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.|[2]Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.|[3]Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.|[4]Lee YT, et al. Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid. Eur J Pharmacol. 1999 Aug 13;378(3):349-56.
CAS Number
– 644-62-2
Molecular Weight
– 296.15
Compound Purity
– 98.0
SMILES
– O=C(O)C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl
Clinical Information
– Launched
Research Area
– Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
– Methanol : 7.14 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;Fat Mass and Obesity-associated Protein (FTO);Gap Junction Protein;Potassium Channel
Pathway
– Cytoskeleton;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
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