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XAV-939

SKU T1878-1 mL * 10 mM (in DMSO) Category Small Compound Tag Top-SmallMol Brand: TargetMol

Price range: 77 CAD through 784 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1878

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H11F3N2OS

Citations

– 1. Wu M, Zhang X, Zhang W, et al. Cancer Stem Cell Regulated Phenotypic Plasticity Protects Metastasized Cancer Cells from Ferroptosis. Nature Communications. 2022, 13(1): 1-16.2. Liu X, Xie P, Hao N, et al. HIF-1–regulated expression of calreticulin promotes breast tumorigenesis and progression through Wnt/β-catenin pathway activation. Proceedings of the National Academy of Sciences. 2021, 118(44)3. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway,Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.4. Li X Y, Shi J, Zhao W, et al. Wnt16 from decidual stromal cells regulates HTR8/SVneo trophoblastic cell function via Akt/β-catenin pathway. Reproduction. 2022, 1(aop).5. Zhou M, He J, Li Y, et al.N6-methyladenosine modification of REG1α facilitates colorectal cancer progression via β-catenin/MYC/LDHA axis mediated glycolytic reprogramming.Cell Death & Disease.2023, 14(8): 557.6. Wu M, Zhang X, Zhang W, et al.Paracrine secretion of IL8 by breast cancer stem cells promotes therapeutic resistance and metastasis of the bulk tumor cells.Cell Communication and Signaling.2023, 21(1): 1-17.7. Sun R, Luo Y, Liu J, et al.Carbon Dioxide Fractional Laser Treatment Induces Lgr5+ Stem Cell Activation and Hair Regrowth Through the Canonical Wnt/β-Catenin Pathway.Aesthetic Plastic Surgery.2023: 1-15.8. Yan L, Wu M, Wang T, et al.Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming that Drives Immune Evasion.Cancer Research.20249. Chen S, Huang C S, Li K, et al.Tumor initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice.The Journal of Clinical Investigation.2025

References

– Huang SM, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009 Oct 1;461(7264):614-20.

CAS Number

– 284028-89-3

Molecular Weight

– C14H11F3N2OS

Compound Purity

– 0.989

SMILES

– FC(F)(F)C1=CC=C(C=C1)C1=NC(=O)C2=C(CCSC2)N1

Target

– Others

Pathway

– Stem Cells|||Cytoskeletal Signaling|||Chromatin/Epigenetic|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.