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Products Details
Product Description
– WX-081, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. WX-081 exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. WX-081 also inhibits hERG channel with the IC50 of 1.89 μM.
Web ID
– HY-146158
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C34H33ClN2O2
References
– [1]Zhigang Huang, et al. Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent. Bioorg Med Chem Lett. 2022 Sep 1;71:128824.
CAS Number
– 1859978-72-5
Molecular Weight
– 537.09
SMILES
– CN(C)CC[C@@](O)(C1=CC=CC2=C1C=CC=C2)[C@H](C3=CC=CC=C3)C4=C(N=CC(C5=CC=C(C=C5)Cl)=C4)OC
Clinical Information
– Phase 2
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Potassium Channel
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Reference compound
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