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TH287 hydrochloride

SKU T2069L-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 74 CAD through 600 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– TH287 is a selective MTH1 inhibitor(IC50: 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2069L

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C11H11Cl3N4

References

– Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.

CAS Number

– 1638211-05-8

Molecular Weight

– C11H11Cl3N4

Compound Purity

– 0.995

SMILES

– NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl

Target

– Src

Pathway

– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.