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SPDP
$42 – $964
Products Details
Product Description
– SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1][2].
Web ID
– HY-100216
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Molecular Formula
– C12H12N2O4S2
References
– [1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.
CAS Number
– 68181-17-9
Molecular Weight
– 312.36
Compound Purity
– 98.84
SMILES
– O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 155 mg/mL (ultrasonic)
Target
– ADC Linker
Isoform
– Cleavable Linker;Disulfide Cleavable Linker
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
