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SK-575
Price range: 171 CAD through 3,504 CAD
Products Details
Product Description
– SK-575 is a degradation agent targeting protein-hydrolyzed PARP1 chimera with anticancer and antitumor activity.SK-575 effectively inhibits the growth of cancer cells harboring BRCA1/2 mutations and selectively induces PARP1 degradation in cancer cells.
Web ID
– T69596
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C47H53FN8O8
References
– Cao C, et al. Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. J Med Chem. 2020 Oct 8;63(19):11012-11033.
CAS Number
– 2523016-96-6
Molecular Weight
– C47H53FN8O8
Compound Purity
– 0.9939
SMILES
– O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=O)CCCCCCCCCCC(=O)NCCNC5=CC=CC=6C(=O)N(C(=O)C56)C7C(=O)NC(=O)CC7)CC4
Pathway
– Chromatin/Epigenetic|||DNA Damage/DNA Repair
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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