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Natalizumab
$515 – $1,200
Products Details
Product Description
– Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn’s disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses[1].
Web ID
– HY-108831
Storage Temperature
– Store at 4°C for 2 years, do not freeze
Shipping
– Isolate blue ice and the product with bubble pack to avoid direct contact
Applications
– COVID-19-immunoregulation
Molecular Formula
– N/A
References
– [1]Hutchinson M. Natalizumab: A new treatment for relapsing remitting multiple sclerosis. Ther Clin Risk Manag. 2007 Jun;3(2):259-68.
CAS Number
– 189261-10-7
Molecular Weight
– N/A
Compound Purity
– 99.10
SMILES
– [Natalizumab]
Clinical Information
– Launched
Research Area
– Inflammation/Immunology
Solubility
– H2O
Target
– Integrin
Isoform
– α4β1
Pathway
– Cytoskeleton
Product type
– Inhibitory Antibodies
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
