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JSH-23

SKU T1930-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 58 CAD through 725 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

2 mg 1 mg 1 mL * 10 mM (in DMSO)10 mg 100 mg 25 mg 5 mg 50 mg

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Products Details

Product Description

– JSH-23 is an NF-κB inhibitor that inhibits NF-κB transcriptional activity (IC50=7.1 μM) but does not affect IκBα degradation. JSH-23 is an antioxidant with anti-inflammatory activity.

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T1930

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C16H20N2

Citations

– 1. Chen J, Liu G, Wang X, et al. Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling. Cell Stem Cell. 2022 2. Lai X, Wang M, Zhu Y, et al. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting inflammation and keratinocyte apoptosis via nuclear translocation of phosphorylated NF-κB p65 and cysteine deficiency. Journal of Hazardous Materials. 2020: 124566 3. Zhou D, Yang S, Yan H, et al. SC75741, a novel c-Abl inhibitor, promotes the clearance of TDP25 aggregates via ATG5-dependent autophagy pathway. Frontiers in Pharmacology. 2021: 2891. 4. Xia H, Zhang Z, You F. Inhibiting ACSL1-Related Ferroptosis Restrains Murine Coronavirus Infection. Viruses. 2021, 13(12): 2383. 5. Song H, Tang X, Li X, et al. HLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial–Mesenchymal Transition. Drug Design, Development and Therapy. 2020, 14: 4291 6. Zhang Q, Qian Y, Ren Y, et al.Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification.Acta Pharmacologica Sinica.2023: 1-14. 7. Kuang B, Geng N, Yi M, et al.Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.Journal of Advanced Research.2024 8. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting nuclear translocation of p-NFκB p65 and cysteine deficiency in keratinocytes

References

– Shin HM, et al. FEBS Lett. 2004, 571(1-3), 50-54.

CAS Number

– 749886-87-1

Molecular Weight

– C16H20N2

Compound Purity

– 0.9967

SMILES

– Cc1ccc(NCCCc2ccccc2)c(N)c1

Target

– Others

Pathway

– NF-κB

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.