– BAOP-16 is a near-infrared fluorescent probe (NIRF) designed specifically to target various soluble Aβ aggregates. This probe has a “y” shaped molecular structure, and its fluorescence intensity significantly increases when it binds to soluble Aβ aggregates in the near-infrared region, exhibiting high affinity. Additionally, BAOP-16 is capable of detecting Aβ oligomers in the brains of Aβ-inoculated model mice. In vivo fluorescence imaging studies of BAOP-16 have shown that the brains of AD model mice exhibit significantly higher fluorescence signals than those of wild-type mice. These findings indicate that BAOP-16 can be used for in vivo NIRF imaging to effectively identify various soluble Aβ aggregates.