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Products Details
Product Description
– ALK-IN-23 is a potent ALK inhibitor with IC50 values of 1.6 nM, 0.71 nM and 1.3 nM for ALKWT, ALKL1196M and ALKG1202R. ALK-IN-23 can block cell cycle in G2 phase and induce apoptosis. ALK-IN-23 inhibits cancer cell migration and colony formation in vitro. ALK-IN-23 exhibits antitumor activity in H2228 xenograft nude mice model with hypotoxicity[1].
Web ID
– HY-151155
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H29ClN8O3S
References
– [1]Yang J, et al. Design, synthesis and antitumor evaluation of ATP dual-mimic 2,4-diarylaminopyrimidine and aminoindazole conjugates as potent anaplastic lymphoma kinase inhibitors. Eur J Med Chem. 2022 Jul 31;241:114626.
Molecular Weight
– 569.08
SMILES
– CC(S(=O)(C1=CC=CC=C1NC2=NC(NC3=CC=C4C(NN=C4NC(CN5CCCC5)=O)=C3)=NC=C2Cl)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK)
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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