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A-381393
$71 – $950
Products Details
Product Description
– A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1].
Web ID
– HY-116941
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H24N4
References
– [1]Nakane M, et al. 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21.
CAS Number
– 726174-00-1
Molecular Weight
– 320.43
Compound Purity
– 99.90
SMILES
– CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 51.67 mg/mL (ultrasonic)
Target
– Dopamine Receptor
Isoform
– D3 Receptor;D4 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
