(E/Z)-Rigosertib sodium
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(E/Z)-Rigosertib sodium

SKU T6070-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 995 CAD

Products Details

Product Description

– ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.

Web ID

– T6070

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C21H24NNaO8S

References

– Gumireddy K , Reddy M V R , Cosenza S C , et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.[J]. Cancer Cell, 2005, 7(3):275-286.

CAS Number

– 1225497-78-8

Molecular Weight

– C21H24NNaO8S

Compound Purity

– 0.9911

SMILES

– [Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1

Pathway

– Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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