XMU-MP-1
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XMU-MP-1

SKU T4212-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 77 CAD through 1,173 CAD

Products Details

Product Description

– XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.

Web ID

– T4212

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C17H16N6O3S2

Citations

– 1. Wang H, Shang Y, Wang E, et al. MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer’s disease. Progress in Neurobiology. 2022: 102280 2. Yang L, Li N, Yang D, et al. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation. Cell Death & Differentiation. 2021: 1-18 3. Zhu Y, Gu H, Yang L, et al. Involvement of MST1/mTORC1/STAT1 activity in the regulation of B-cell receptor signalling by chemokine receptor 2. Clinical and Translational Medicine. 2022, 12(7): e887. 4. Shang Y, Yan Y, Chen B, et al. Over‐expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice. Genes, Brain and Behavior. 2020: e12678 5. Xu W, Shi Z, Yu X, et al.Salvianolic acid B exerts an anti-hepatocellular carcinoma effect by regulating the Hippo/YAP pathway and promoting pSmad3L to pSmad3C simultaneously.European Journal of Pharmacology.2022: 175423. 6. Lin G, Xia A, Qiao J, et al.Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo.Biochemical Pharmacology.2024: 116217. 7. Zhu C, Zheng R, Han X, et al.Knockout of integrin αvβ6 protects against renal inflammation in chronic kidney disease by reduction of pro-inflammatory macrophages.Cell Death & Disease.2024, 15(6): 397. 8. Effects of YAP Inhibitors and Activators on the Growth of Leukemia Cells[J]. Anticancer Research, 2025, 45(3): 977-987.

References

– Fan F, et al. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci Transl Med. 2016 Aug 17;8(352):352ra108.

CAS Number

– 2061980-01-4

Molecular Weight

– C17H16N6O3S2

Compound Purity

– 0.9968

SMILES

– CN1c2ccsc2C(=O)N(C)c2cnc(Nc3ccc(cc3)S(N)(=O)=O)nc12

Pathway

– Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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