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Temuterkib
Price range: 102 CAD through 2,976 CAD
Products Details
Product Description
– Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity.
Web ID
– T4091
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C22H27N7O2S
Citations
– 1. Li X, Qin X, Tian J, et al. Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway. Food and Chemical Toxicology. 2020: 111801
2. Chen S J, Huang Y, Yu F, et al.BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2. 5-aggravated asthma.Cell Communication and Signaling.2023, 21(1): 39.
References
– Shripad V. Bhagwat, et al. Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations. Cancer Research. July 2017.
CAS Number
– 1951483-29-6
Molecular Weight
– C22H27N7O2S
Compound Purity
– 0.9957
SMILES
– Cn1nccc1Nc1nccc(n1)-c1cc2C(=O)N(CCN3CCOCC3)C(C)(C)c2s1
Pathway
– MAPK
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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