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YZ129
$60 – $650
Products Details
Product Description
– YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].
Web ID
– HY-114413
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H12N2O2
References
– [1]Liu Z, et al. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2018 Nov 30. pii: S2451-9456(18)30431-8.
CAS Number
– 1643120-60-8
Molecular Weight
– 300.31
Compound Purity
– 99.85
SMILES
– O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 5.6 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– Apoptosis;HSP
Isoform
– HSP90
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
