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Aspirin
$55 – $106
Products Details
Product Description
– Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis[1][2][3][4][5][6].
Web ID
– HY-14654
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C9H8O4
References
– [1]Burch JW, et al. Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest. 1978 Feb;61(2):314-9.|[2]Elwood PC, et al. Aspirin, salicylates, and cancer. Lancet. 2009 Apr 11;373(9671):1301-9.|[3]Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicol Appl Pharmacol. 1972 Aug;22(4):672-5.|[4]Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.|[5]Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73.|[6]Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12.|[7]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.
CAS Number
– 50-78-2
Molecular Weight
– 180.16
Compound Purity
– 99.98
SMILES
– OC(C1=C(OC(C)=O)C=CC=C1)=O
Clinical Information
– Launched
Research Area
– Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility
– DMSO : 400 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Caspase;COX;Mitophagy;NF-κB;p38 MAPK;Virus Protease
Isoform
– COX-1;COX-2
Pathway
– Anti-infection;Apoptosis;Autophagy;Immunology/Inflammation;MAPK/ERK Pathway;NF-κB
Product type
– Reference compound
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