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Vismodegib

SKU T2590-1 mL * 10 mM (in DMSO) Category Small Compound Brand: TargetMol

Price range: 61 CAD through 176 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

Size

1 mL * 10 mM (in DMSO)10 mg 100 mg 200 mg 5 mg 50 mg

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Products Details

Product Description

– Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T2590

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H14Cl2N2O3S

Citations

– 1. Hu A, Zhang J Z, Wang J, et al. Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate. Cell Research. 2022, 32(3): 288-301. 2. Wu Q, Huang Q, Jiang Y, et al. Remodeling Chondroitin-6-Sulfate–Mediated Immune Exclusion Enhances Anti–PD-1 Response in Colorectal Cancer with Microsatellite Stability. Cancer Immunology Research. 2021 3. Wu Q, Huang Q, Jiang Y, et al. Remodeling Chondroitin-6-Sulfate–Mediated Immune Exclusion Enhances Anti–PD-1 Response in Colorectal Cancer with Microsatellite Stability. Cancer Immunology Research. 2021 4. Wu H, Zhang L, Chen B, et al.B13, a well-tolerated inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against colorectal carcinoma in vitro and in vivo.Bioorganic Chemistry.2023: 106488.

References

– Scales SJ, et al. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009 Jun;30(6):303-12.

CAS Number

– 879085-55-9

Molecular Weight

– C19H14Cl2N2O3S

Compound Purity

– 0.9999

SMILES

– ClC=1C(=CC(NC(=O)C2=C(Cl)C=C(S(C)(=O)=O)C=C2)=CC1)C3=CC=CC=N3

Pathway

– GPCR/G Protein|||Autophagy|||Membrane transporter/Ion channel|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.