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Vacuolin-1

SKU T21992-1 mg Category Small Compound Brand: TargetMol

Price range: 50 CAD through 926 CAD

For Research Use Only (RUO). This product is sold strictly for laboratory research use. Not for human or veterinary consumption, therapeutic, or diagnostic use.For sale to research organizations and laboratories only; not for patients or for personal use.

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Products Details

Product Description

– Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits late‐stage autophagy by impairing lysosomal maturation

For Research Use Only (RUO). This product is sold strictly for laboratory research use only. Not for human or veterinary consumption, therapeutic, or diagnostic use. Any pharmacological, therapeutic, cosmetic, or biological effects described above are provided as research context only and do not represent intended or approved uses of this product.

Web ID

– T21992

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H24IN7O

Citations

– 1. Yan R, Zhang P, Shen S, et al.Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion.Nature Immunology.2024: 1-13.

References

– Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy

CAS Number

– 351986-85-1

Molecular Weight

– C26H24IN7O

Compound Purity

– 0.972

SMILES

– Ic1cccc(C=NNc2nc(nc(n2)N2CCOCC2)N(c2ccccc2)c2ccccc2)c1

Pathway

– PI3K/Akt/mTOR signaling|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.