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(S,S)-BMS-984923
$500
Only 1000 item(s) left in stock.
Products Details
Product Description
– (S,S)-BMS-984923 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 shows an EC50 >1μM for mGluR5 receptor[1]. BMS-984923 is a potent mGluR5 silent allosteric modulator[2]. (S,S)-BMS-984923 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-141848A
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Molecular Formula
– C22H15ClN2O2
References
– [1]Andrew P. Degnan, et al. Oxazolidinones as modulators of mglur5. WO2012064603A1.|[2]Laura T Haas, et al. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.
CAS Number
– 1375752-77-4
Molecular Weight
– 374.82
Compound Purity
– 98.82
SMILES
– ClC1=C(C=CC=C1)[C@@]2([H])[C@@](C3=CN=CC(C#CC4=CC=CC=C4)=C3)([H])NC(O2)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mGluR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
